As the science of nutrition continually evolves, researchers recognize that nutrients needed to maintain a healthy lifestyle must be tailored to the individual for maximum effectiveness. Recognizing that people are not all alike and that one size does not fit all when it comes to planning and achieving a healthful diet, the Institute of Medicine's dietary guidelines, titled "Dietary Reference Intakes for Macronutrients," stress the importance of balancing diet with exercise and recommends total calories based on an individual's height, weight and gender for each of four different levels of physical activity.

^ Jump up to: a b c Aldridge, Robert W.; Story, Alistair; Hwang, Stephen W.; Nordentoft, Merete; Luchenski, Serena A.; Hartwell, Greg; Tweed, Emily J.; Lewer, Dan; Vittal Katikireddi, Srinivasa (2017-11-10). "Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis". Lancet. 391 (10117): 241–250. doi:10.1016/S0140-6736(17)31869-X. ISSN 1474-547X. PMC 5803132. PMID 29137869. All-cause standardised mortality ratios were significantly increased in 91 (99%) of 92 extracted datapoints and were 11·86 (95% CI 10·42–13·30; I2=94·1%) in female individuals
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